Innovating drug delivery solutions for advanced therapies
Solving the complexities of formulation, containment and delivery in next generation therapies.
Delivering advanced formulations requires more than innovation - it demands a seamless integration of formulation, device design and scalability. Addressing the challenges like high-viscosity formulations and precision delivery for personalised therapies calls for multidisciplinary expertise. By anticipating bottlenecks early, teams can unlock the full potential of next-generation treatments, improving outcomes and accelerating time to market.
Tackling the challenges of next-generation drug modalities
Next-generation therapies are redefining treatment possibilities - but translating innovation into real-world solutions requires overcoming significant formulation and delivery hurdles. Higher concentration monoclonal antibodies (mAbs) increase potency, viscosity, and delivery volumes beyond current system capacities.
Personalised therapies, like cell, gene, and lipid nanoparticle (LNP) treatments, require precise handling, while particulate suspensions demand advanced resuspension and delivery techniques.
Success demands expertise in fluid dynamics, dosing strategies, and patient-focused design.
Below we delve deeper into these critical topics - exploring the challenges, uncovering new insights, and sharing strategies to advance drug delivery technologies for the therapies of tomorrow.
Drug delivery for advanced therapies – from targeting tumours to crossing the blood-brain barrier
Advanced therapies hold remarkable potential for indications from oncology to regenerative medicine.
Yet, with a diversity of modalities their successful delivery often poses challenges - whether it’s ensuring precision targeting, mitigating immune response, or addressing cost and usability constraints.
So how can we advance the delivery of these complex therapies?
TTP’s Stuart Lowe, Head of Advanced Therapies, and Matt Parker, Device Innovation Lead recently sat down to share expert insights into overcoming drug delivery challenges and key device considerations for advanced therapies. Watch the video or read the shorter summary.
Meet us at
Room temperature-stable mRNA therapeutics: a breakthrough for global access
mRNA technologies have enabled the rapid development of vaccines, but widespread use is constrained by the need for ultra-cold storage. To open up new possibilities not only for transportation but also for drug delivery into the body, we’ve taken on the challenge of developing a process for making dry powder mRNA formulations that are stable at room temperature. Find out how we've been addressing room-termperature-stable mRNA.
Drug Delivery at TTP
From blank sheet to clinical reality, TTP's Drug Delivery team creates groundbreaking solutions to solve the toughest drug delivery challenges. Our proven capabilities in fluid modelling, material science, human factors and device development enable scalable, next-generation drug delivery solutions, empowering transformative outcomes in patient care.
Find out how TTP's Drug Delivery product development team can support your technology ambitions.
.avif)
When we received the new moulded parts incorporating TTP’s recommendations, all of them performed as intended and within specification. We were really excited.
Justin Creel
Vice President of Device Development
TTP have been an invaluable long-term partner for AstraZeneca. They have both the deep expertise and creativity to generate innovative concepts, and the horsepower to accelerate these through design verification.
Dan Deaton
Executive Director, Patient Experience & Innovation at AstraZeneca
TTP has been an incredible partner, complementing our expertise and delivering designs from white board to moulded functional prototypes. With TTP’s support, Achilles is scaling our manufacturing process and bringing transformative therapies from bench to bedside. The TTP team has shown the same level of excitement as us in getting these therapies to the people who need them.
Ed Samuel
EVP Technical Operations
Our areas of focus:
Medical Devices & Drug Delivery
Our approach and capabilities
We deliver across the entire life of a project, from opportunity discovery to production engineering. Discover how our interdisciplinary teams of experts collaborate to tackle the toughest product development challenges.
Our campus and facilities
Our award-winning campus has been designed with a clear vision. To create space which can suport our people and our clients as we develop and deliver the very best technology solution.
Software capability at TTP
Engaged in all stages of software and product development, our software capability at TTP covers the full spectrum—from in-depth analysis and system architecture to prototype design, implementation, and test development.
Manufacturing capability at TTP
Working seamlessly with our development teams, we take clients' products through prototype builds, clinical trials, pilot manufacture and more. Using TTP Manufacturing reduces uncertainty, risk and time to market for our clients.
Meet some of the team
